In todayââ?¬â?¢s aging society, more people are living with lifestyle-related noncommunicable diseases (NCDs) such as cardiovascular\ndisease, type 2 diabetes, obesity, and cancer. Numerous opinion-leader organizations recommend lifestyle medicine as the firstline\napproach in NCD prevention and treatment. However, there is a strong need for a personalized approach as ââ?¬Å?one-size-fits-allââ?¬Â\npublic health recommendations have been insufficient in addressing the interindividual differences in the diverse populations.\nAdvancement in systems biology and the ââ?¬Å?omicsââ?¬Â technologies has allowed comprehensive analysis of how complex biological\nsystems are impacted upon external perturbations (e.g., nutrition and exercise), and therefore is gradually pushing personalized\nlifestyle medicine toward reality. Clinicians and healthcare practitioners have a unique opportunity in advocating lifestyle\nmedicine because patients see them as a reliable source of advice. However, there are still numerous technical and logistic\nchallenges to overcome before personal ââ?¬Å?big dataââ?¬Â can be translated into actionable and clinically relevant solutions. Clinicians are\nalso facing various issues prior to bringing personalized lifestyle medicine to their practice. Nevertheless, emerging groundbreaking\nresearch projects have given us a glimpse of how systems thinking and computational methods may lead to personalized\nhealth advice. It is important that all stakeholders work together to create the needed paradigm shift in healthcare before the rising\nepidemic of NCDs overwhelm the society, the economy, and the dated health system.
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